The Nature of Antigen-antibody Complexes Formed in Rabbits during an Immune Response to Bovine Serum Albumin
نویسنده
چکیده
The immune elimination of soluble BSA, following an intravenous injection, is accompanied by the appearance of circulating antigen-antibody complexes. The pattern of the appearance of circulating antigen-antibody complexes and the immune elimination of antigen probably depends on the amount of antigen injected, the rate of antibody synthesis, and perhaps, the quality of antibody produced. There is no relationship between the I* antigen-antibody complexes detected during the immune response in rabbits by ammonium sulfate precipitation and the material precipitated from immune sera as a result of treatment with alkali. Alkali-precipitable material present in the serum of rabbits at a time when I* antigen is also present contain at most only traces of the antigen.
منابع مشابه
Polyclonal antibody production against bovine serum albumin conjugated artemisinin in rabbit
Abstract: The aim of the present study was to produce a polyclonal antibody against bovine serum albumin (BSA) conjugated with artemisinin. To gain an immunogenic character of artemisinin, a carboxyl group was added to it using mixed anhydride method. Then, the reactive compound of artemisinin was conjugated with BSA. The BSA+artemisinin were injected to white female New Zealand rabbits for two...
متن کاملExperimental Immune Complex Disease of the Lung
Membranous and/or proliferative pneumonitis, similar in certain features to human interstitial pneumonitis, developed in rabbits making hyperactive antibody response to daily injections of bovine serum albumin (BSA) administered in multiple large doses sufficient to maintain the state of relative antigen-antibody equivalence. The pulmonary lesions were associated with deposition in alveolar cap...
متن کاملAcute I M M U N E Complex Disease I N Rabbits* the Role of Complement and of a Leukocyte-dependent Release of Vasoactive Amines from Platelets
Acute immune complex disease (serum sickness) in rabbits may be induced by a single large, intravenous injection of an antigen, such as bovine serum albumin (BSA).I When the animal mounts an immune response against the antigen and synthesizes antibodies, immune complexes between antibody and antigen form and circulate in the blood. Deposition of these complexes in blood vessel walls initiates t...
متن کاملPathogenetic Mechanisms in Experimental Immune Fever
When rabbits sensitized to human serum albumin (HSA) are challenged intravenously with specific antigen, fever develops and two transferable pyrogens can be demonstrated in the circulation. The first appears prior to the development of fever and has properties consistent with soluble antigen-antibody complexes. These have been shown to be pyrogenic when prepared in vitro and to produce a state ...
متن کاملPersistence of Hapten-antibody Complexes in the Circulation of Immunized Animals after a Single Intravenous Injection of Hapten
To study the fate of a low molecular weight antigen (hapten) in the circulation of animals whose sera contain antibodies specific for that low molecular weight antigen, a single injection of digoxin-(3)H (0.4 mg/kg) was administered intravenously to 18 rabbits. Thirteen animals (nine nonimmunized and four immunized with bovine serum albumin) served as control animals. In five rabbits which had ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 107 شماره
صفحات -
تاریخ انتشار 1958